Are adipokines the missing link between obesity, immune response, and outcomes in severe COVID-19?

ABSTRACT:

Introduction

Obesity is commonly reported in COVID-19 patients and is associated with poorer outcomes. It is suggested that leptin could be the missing link between obesity and severe COVID-19. Our study aimed to unravel the link between adipokines, COVID-19 status, immune response, and outcomes in severe pneumonia.

Methods

In this prospective observational single-center study, 63 immunocompetent patients with severe pneumonia (36 non-COVID-19 and 27 COVID-19) were enrolled, most required intensive care. Clinical and biological characteristics (glucose metabolism, plasma adipokines, and cytokine concentrations) and outcomes were compared.

Results

At similar baseline severity, COVID-19 patients required mechanical ventilation for significantly longer than non-COVID-19

SUBMITTER: Blot M 

PROVIDER: S-EPMC8166380 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature