Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality.

ABSTRACT:

Objective

To investigate whether cholinesterase inhibitors (ChEIs) are associated with slower cognitive decline in Alzheimer dementia and decreased risk of severe dementia or death.

Methods

Patients with Alzheimer dementia from the Swedish Dementia Registry starting on ChEIs within 3 months of the dementia diagnosis were included and compared to nontreated patients with Alzheimer dementia. In a propensity score-matched cohort, the association between ChEI use and cognitive trajectories assessed by Mini-Mental State Examination (MMSE) scores was examined with a mixed model, and severe dementia (MMSE score <10) or death as an outcome was assessed with Cox proportional hazards models.

Results

The matched cohort included 11,652 ChEI users and 5,826 nonusers. During an ave

SUBMITTER: Xu H 

PROVIDER: S-EPMC8166426 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature