Cardiovascular Risk Factors Across the Life Course and Cognitive Decline: A Pooled Cohort Study.

ABSTRACT:

Objective

Cardiovascular risk factors (CVRFs) are associated with increased risk of cognitive decline, but little is known about how early adult CVRFs and those across the life course might influence late-life cognition. To test the hypothesis that CVRFs across the adult life course are associated with late-life cognitive changes, we pooled data from 4 prospective cohorts (n = 15,001, ages 18-95).

Methods

We imputed trajectories of body mass index (BMI), fasting glucose (FG), systolic blood pressure (SBP), and total cholesterol (TC) for older adults. We used linear mixed models to determine the association of early adult, midlife, and late-life CVRFs with late-life decline on global cognition (Modified Mini-Mental State Examination [3MS]) and processing speed (Digit Symbol S

SUBMITTER: Yaffe K 

PROVIDER: S-EPMC8166431 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature