Randomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache.

ABSTRACT:

Objective

To determine whether IV metoclopramide 20 mg + diphenhydramine 25 mg (M + D) was more efficacious than IV placebo for acute moderate or severe posttraumatic headache in the emergency room.

Methods

We conducted this randomized, double-blind, placebo-controlled, parallel-group study in 2 urban emergency departments (EDs). Participants who experienced head trauma and presented to our EDs within 10 days with a headache fulfilling criteria for acute posttraumatic headache were included. We randomized participants in a 1:1 ratio to M + D or placebo. Participants, caregivers, and outcome assessors were blinded to assignment. The primary outcome was improvement in pain on a scale of 0 to 10 between baseline and 1 hour after treatment.

Results

This study was complete

SUBMITTER: Friedman BW 

PROVIDER: S-EPMC8166438 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature