Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease.

ABSTRACT:

Objective

To test the hypothesis that the APOE genotype is a significant driver of heterogeneity in Alzheimer disease (AD) clinical progression, which could have important implications for clinical trial design and interpretation.

Methods

We applied novel reverse-time longitudinal models to analyze the trajectories of Clinical Dementia Rating Sum of Boxes (CDR-SOB) and Mini-Mental State Examination (MMSE) scores-2 common outcome measures in AD clinical trials-in 1,102 autopsy-proven AD cases (moderate/frequent neuritic plaques and Braak tangle stage III or greater) from the National Alzheimer's Coordinating Center Neuropathology database resembling participants with mild to moderate AD in therapeutic clinical trials.

Results

APOE ε4 carriers exhibited ≈1

SUBMITTER: Qian J 

PROVIDER: S-EPMC8166439 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature