Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease.

ABSTRACT:

Objective

To assess the prevalence, timing, and functional impact of psychiatric, cognitive, and motor abnormalities in Huntington disease (HD) gene carriers, we analyzed retrospective clinical data from individuals with manifest HD.

Methods

Clinical features of patients with HD were analyzed for 6,316 individuals in an observational study of the European Huntington's Disease Network (REGISTRY) from 161 sites across 17 countries. Data came from clinical history and the patient-completed Clinical Characteristics Questionnaire that assessed 8 symptoms: motor, cognitive, apathy, depression, perseverative/obsessive behavior, irritability, violent/aggressive behavior, and psychosis. Multiple logistic regression was used to analyze relationships between symptoms and functional out

SUBMITTER: McAllister B 

PROVIDER: S-EPMC8166441 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature