Identification and Verification of a 17 Immune-Related Gene Pair Prognostic Signature for Colon Cancer.

ABSTRACT:

Background

Colon cancer (CC) is a malignant tumor with a high incidence and poor prognosis. Accumulating evidence shows that the immune signature plays an important role in the tumorigenesis, progression, and prognosis of CC. Our study is aimed at establishing a novel robust immune-related gene pair signature for predicting the prognosis of CC.

Methods

Gene expression profiles and corresponding clinical information are obtained from two public data sets: The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO, GSE39582). We screened out immune-related gene pairs (IRGPs) associated with prognosis in the discovery cohort. Lasso-Cox proportional hazard regression was used to develop the best prognostic signature model. According to this, the patients in the validation c

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC8166469 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature