Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs).

ABSTRACT:

Background

The host's immune system develops in equilibrium with both cellular self-antigens and non-self-antigens derived from microorganisms which enter the body during lifetime. In addition, during the years, a tumor may arise presenting to the immune system an additional pool of non-self-antigens, namely tumor antigens (tumor-associated antigens, TAAs; tumor-specific antigens, TSAs).

Methods

In the present study, we looked for homology between published TAAs and non-self-viral-derived epitopes. Bioinformatics analyses and ex vivo immunological validations have been performed.

Results

Surprisingly, several of such homologies have been found. Moreover, structural similarities between paired TAAs and viral peptides as well as comparable patterns of contact with HLA a

SUBMITTER: Ragone C 

PROVIDER: S-EPMC8166618 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature