Thinner temporal peripapillary retinal nerve fibre layer in Stargardt disease detected by optical coherence tomography.

ABSTRACT:

Purpose

To evaluate peripapillary retinal nerve fibre layer (RNFL) thickness measured by spectral domain optical coherence tomography (OCT) in patients with Stargardt disease (STGD).

Methods

A cross-sectional, monocentric, observational case-control study. Twenty patients (39 eyes) with ABCA4 mutations graded according to the Fishman STGD classification were included. RNFL measurement was performed using Heidelberg Spectralis SD-OCT. RNFL thickness in STGD patients was compared to age-matched data of healthy individuals provided by the device's manufacturer. A manual readjustment of the optic disc-fovea angle was performed when needed.

Results

The mean age at first diagnosis of STGD was 22.9 years (range 9 to 50) and 39.1 years (range 18 to 74) at the time of examinat

SUBMITTER: Reich M 

PROVIDER: S-EPMC8166683 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature