Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment.

ABSTRACT: In view of the need to enhance the assessment of consumer products called for in the EU Chemicals Strategy for Sustainability, we developed a methodology for evaluating hazard by combining information across different systemic toxicity endpoints and integrating the information with new approach methodologies. This integrates mechanistic information with a view to avoiding redundant in vivo studies, minimising reliance on apical endpoint tests and ultimately devising efficient testing strategies. Here, we present the application of our methodology to carcinogenicity assessment, mapping the available information from toxicity test methods across endpoints to the key characteristics of carcinogens. Test methods are deconstructed to allow the information they provide to be organised in a syste

SUBMITTER: Madia F 

PROVIDER: S-EPMC8166685 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature