Refractory neovascular age-related macular degeneration: time-dependent changes of central retinal thickness with anti-VEGF treatment.

ABSTRACT:

Purpose

To assess the influence of time interval since last injection and time from baseline on central retinal thickness (CRT) in neovascular age-related macular degeneration (nAMD) with fluid refractory to monthly anti-VEGF treatment.

Methods

This retrospective study included nAMD eyes with incomplete response to anti-VEGF defined by the presence of intra- or subretinal fluid on optical coherence tomography despite maximal (monthly) anti-VEGF dosing. The outcome measure was CRT, and two time variables (time from last injection ant time from baseline) were the independent factors included in the individual correlation analyses. In addition, an association analysis was performed.

Results

Sixty eyes of 56 patients (67.9% females, mean age: 78.7 ± 6.8 years) were includ

SUBMITTER: Zola M 

PROVIDER: S-EPMC8166689 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature