Behavioral phenotypes of temporal lobe epilepsy.

ABSTRACT:

Objective

To identity phenotypes of self-reported symptoms of psychopathology and their correlates in patients with temporal lobe epilepsy (TLE).

Method

96 patients with TLE and 82 controls were administered the Symptom Checklist 90-Revised (SCL-90-R) to characterize emotional-behavioral status. The nine symptom scales of the SCL-90-R were analyzed by unsupervised machine learning techniques to identify latent TLE groups. Identified clusters were contrasted to controls to characterize their association with sociodemographic, clinical epilepsy, neuropsychological, psychiatric, and neuroimaging factors.

Results

TLE patients as a group exhibited significantly higher (abnormal) scores across all SCL-90-R scales compared to controls. However, cluster analysis identified th

SUBMITTER: Hermann BP 

PROVIDER: S-EPMC8166791 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature