Heat stress and immune response phenotype affect DNA methylation in blood mononuclear cells from Holstein dairy cows.

ABSTRACT: Heat stress negatively affects health and production in cows. Examining the cellular response to heat stress could reveal underlying protective molecular mechanisms associated with superior resilience and ultimately enable selection for more resilient cattle. This type of investigation is increasingly important as future predictions for the patterns of heat waves point to increases in frequency, severity, and duration. Cows identified as high immune responders based on High Immune Response technology (HIR) have lower disease occurrence compared to their average and low immune responder herd-mates. In this study, our goal was to identify epigenetic differences between high and low immune responder cows in response to heat stress. We examined genome-wide DNA methylation of blood mononuclear

SUBMITTER: Livernois AM 

PROVIDER: S-EPMC8166884 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature