Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson's disease.

ABSTRACT: Alterations in the metabolism of iron and its accumulation in the substantia nigra pars compacta accompany the pathogenesis of Parkinson's disease (PD). Changes in iron homeostasis also occur during aging, which constitutes a PD major risk factor. As such, mitigation of iron overload via chelation strategies has been considered a plausible disease modifying approach. Iron chelation, however, is imperfect because of general undesired side effects and lack of specificity; more effective approaches would rely on targeting distinctive pathways responsible for iron overload in brain regions relevant to PD and, in particular, the substantia nigra. We have previously demonstrated that the Transferrin/Transferrin Receptor 2 (TfR2) iron import mechanism functions in nigral dopaminergic neurons, is

SUBMITTER: Milanese C 

PROVIDER: S-EPMC8166951 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature