Novel Anti-Cytokine Strategies for Prevention and Treatment of Respiratory Allergic Diseases.

ABSTRACT: Asthma is a heterogeneous inflammatory disease characterized by airflow obstruction, wheezing, eosinophilia and neutrophilia of the airways. Identification of distinct inflammatory patterns characterizing asthma endotypes led to the development of novel therapeutic approaches. Cytokine or cytokine receptor targeting by therapeutic antibodies, such as anti-IL-4 and anti-IL-5, is now approved for severe asthma treatment. However, the complexity of cytokine networks in asthma should not be underestimated. Inhibition of one pro-inflammatory cytokine may lead to perturbed expression of another pro-inflammatory cytokine. Without understanding of the underlying mechanisms and defining the molecular predictors it may be difficult to control cytokine release that accompanies certain disease manifes

SUBMITTER: Gubernatorova EO 

PROVIDER: S-EPMC8167041 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature