D-Amphetamine Rapidly Reverses Dexmedetomidine-Induced Unconsciousness in Rats.

ABSTRACT: D-amphetamine induces emergence from sevoflurane and propofol anesthesia in rats. Dexmedetomidine is an α₂-adrenoreceptor agonist that is commonly used for procedural sedation, whereas ketamine is an anesthetic that acts primarily by inhibiting NMDA-type glutamate receptors. These drugs have different molecular mechanisms of action from propofol and volatile anesthetics that enhance inhibitory neurotransmission mediated by GABA_A receptors. In this study, we tested the hypothesis that d-amphetamine accelerates recovery of consciousness after dexmedetomidine and ketamine. Sixteen rats (Eight males, eight females) were used in a randomized, blinded, crossover experimental design and all drugs were administered intravenously. Six additional rats with pre-implanted electro

SUBMITTER: Kato R 

PROVIDER: S-EPMC8167047 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature