Estimation of renal perfusion based on measurement of rubidium-82 clearance by PET/CT scanning in healthy subjects.

ABSTRACT:

Background

Changes in renal blood flow (RBF) may play a pathophysiological role in hypertension and kidney disease. However, RBF determination in humans has proven difficult. We aimed to confirm the feasibility of RBF estimation based on positron emission tomography/computed tomography (PET/CT) and rubidium-82 (⁸²Rb) using the abdominal aorta as input function in a 1-tissue compartment model.

Methods

Eighteen healthy subjects underwent two dynamic ⁸²Rb PET/CT scans in two different fields of view (FOV). FOV-A included the left ventricular blood pool (LVBP), the abdominal aorta (AA) and the majority of the kidneys. FOV-B included AA and the kidneys in their entirety. In FOV-A, an input function was derived from LVBP and from AA, in FOV-B from AA. One-tis

SUBMITTER: Langaa SS 

PROVIDER: S-EPMC8167076 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature