Acoustoelectric imaging of deep dipoles in a human head phantom for guiding treatment of epilepsy.

ABSTRACT:

Objective

This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods.

Approach

This technique exploits an interaction between a focused ultrasound (US) beam and tissue resistivity to localize current source densities as deep as 63 mm at high spatial resolution (1 to 4 mm) and resolve fast time-varying currents with sub-ms precision.

Main results

Detection thresholds through a thick segment of the human skull at biologically safe US intensities was below 0.5 mA and within range of strong currents generated by the human brain.<

SUBMITTER: Barragan A 

PROVIDER: S-EPMC8167191 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature