Comparative analysis of canine mesenchymal stem cells and bone marrow-derived mononuclear cells.

ABSTRACT:

Background and aim

Mesenchymal stem cells (MSCs), which have multi-lineage differentiation potentials, are a promising source for regenerative medicine. However, the focus of study of MSCs is shifting from the characterization of the differentiation potential to their secretion potential for cell transplantation. Tissue regeneration and the attenuation of immune responses are thought to be affected by the secretion of multiple growth factors and cytokines by MSCs. However, the secretion potential of MSCs profiling remains incompletely characterized. In this study, we focused on the secretion ability related and protein mRNA expression of dog adipose tissue-derived MSCs (AT-MSC), bone marrow (BM)-derived MSCs, and BM-derived mononuclear cells (BM-MNC).

Materials and methods

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SUBMITTER: Maeta N 

PROVIDER: S-EPMC8167527 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature