Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing.

ABSTRACT: Hypertrophic scarring (HS) is a dermal fibroproliferative disorder characterized by excessive deposition of collagen and other extracellular matrix components. The aim of this study is to explore crucial long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) associated with HS and provide a better understanding of the molecular mechanism of HS. To investigate the lncRNA, circRNA and mRNA expression profiles, we performed RNA sequencing of human HS and normal skin tissues. After the identification of differentially expressed mRNAs (DEmRNAs), lncRNAs (DElncRNAs) and circRNAs (DEcircRNAs), we performed functional enrichment of DEmRNAs. Further on, we constructed DElncRNA/DEcircRNA-DEmRNA coexpression networks and competing endogenous RNA regulatory networks, and performed functional analy

SUBMITTER: Li X 

PROVIDER: S-EPMC8167876 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature