Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer.

ABSTRACT:

Background & aims

Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress, and novel therapeutic response in PC to develop a biomarker-driven therapeutic strategy targeting DDR and replication stress in PC.

Methods

We interrogated the transcriptome, genome, proteome, and functional characteristics of 61 novel PC patient-derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient-derived xenografts and human PC organoids.

Results

Patient-derived cell lines faithfully recapitulate th

SUBMITTER: Dreyer SB 

PROVIDER: S-EPMC8167930 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature