IMMU-13. CUSTOMIZABLE MULTI-LAMELLAR RNA-NANOPARTICLES FOR PEDIATRIC GLIOMA

ABSTRACT: Abstract

Background

Since the preponderance of pediatric gliomas are mutationally ‘bland,’ immune checkpoint inhibitors are unlikely to mediate therapeutic benefit. Alternately, immunologic response can be induced de novo against pediatric gliomas with mRNA cancer vaccines. Messenger RNA represents a paradigm shift in vaccinology (i.e. COVID-19) given its flexibility, commercialization, and propensity to confer rapid protection with only a single vaccine.

Objective

We sought to develop a new mRNA platform with an optimized backbone for insertion of both personalized and/or “off the shelf’ (i.e. H3K27M) transcripts for rapid induction of anti-tumor activity against pediatric gliomas.

Approach

We synthesized an mRNA backbone with optimized 5’ and 3’ UTRs for delive

SUBMITTER: Mendez-Gomez H 

PROVIDER: S-EPMC8168117 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature