Long-Term Risk of Ovarian Cancer and Borderline Tumors After Assisted Reproductive Technology.

ABSTRACT:

Background

Long-term effects of assisted reproductive technology (ART) on ovarian tumor risk are unknown.

Methods

This nationwide cohort study comprises 30 625 women who received ovarian stimulation for ART in 1983-2000 and 9988 subfertile women not treated with ART. Incident invasive and borderline ovarian tumors were ascertained through linkage with the Netherlands Cancer Registry and the Dutch Pathology Registry until July 2018. Ovarian tumor risk in ART-treated women was compared with risks in the general population and the subfertile non-ART group. Statistical tests were 2-sided.

Results

After a median follow-up of 24 years, 158 invasive and 100 borderline ovarian tumors were observed. Ovarian cancer risk in the ART group was increased compared with the general p

SUBMITTER: Spaan M 

PROVIDER: S-EPMC8168156 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature