Long-Term Cause-Specific Mortality in Hodgkin Lymphoma Patients.

ABSTRACT:

Background

Few studies have examined the impact of treatment-related morbidity on long-term, cause-specific mortality in Hodgkin lymphoma (HL) patients.

Methods

This multicenter cohort included 4919 HL patients, treated before age 51 years between 1965 and 2000, with a median follow-up of 20.2 years. Standardized mortality ratios, absolute excess mortality (AEM) per 10 000 person-years, and cause-specific cumulative mortality by stage and primary treatment, accounting for competing risks, were calculated.

Results

HL patients experienced a 5.1-fold (AEM = 123 excess deaths per 10 000 person-years) higher risk of death due to causes other than HL. This risk remained increased in 40-year survivors (standardized mortality ratio = 5.2, 95% confidence interval [CI] = 4.2 to

SUBMITTER: de Vries S 

PROVIDER: S-EPMC8168246 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature