LazyB: fast and cheap genome assembly.

ABSTRACT:

Background

Advances in genome sequencing over the last years have lead to a fundamental paradigm shift in the field. With steadily decreasing sequencing costs, genome projects are no longer limited by the cost of raw sequencing data, but rather by computational problems associated with genome assembly. There is an urgent demand for more efficient and and more accurate methods is particular with regard to the highly complex and often very large genomes of animals and plants. Most recently, "hybrid" methods that integrate short and long read data have been devised to address this need.

Results

LazyB is such a hybrid genome assembler. It has been designed specificially with an emphasis on utilizing low-coverage short and long reads. LazyB starts from a bipartite overlap graph b

SUBMITTER: Gatter T 

PROVIDER: S-EPMC8168326 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature