Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.

ABSTRACT:

Background

The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.

Objectives

To complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR).

Methods

Two-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetic

SUBMITTER: Tsilidis KK 

PROVIDER: S-EPMC8168352 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature