Prior undernutrition and insulin production several years later in Tanzanian adults.

ABSTRACT:

Background

The prevalence, pathology, and existence of malnutrition-associated diabetes remain uncertain, especially with respect to adult-acquired undernutrition.

Objective

The aim was to investigate the association of prior undernutrition (low BMI, in kg/m2), acquired in adulthood and insulin during an oral glucose tolerance test (OGTT).

Methods

We followed up 630 adults recruited 7-14 y previously for other studies. Plasma insulin was measured fasting and at 30 and 120 min during an OGTT. The main exposure was BMI measured 7-14 y prior. The main outcome of interest was plasma insulin, controlling for time during the OGTT using generalized estimating equations, and exploratory outcomes were early insulin response (relative change in insulin and glucose from 0-30 min

SUBMITTER: Filteau S 

PROVIDER: S-EPMC8168356 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature