Weight stability masks changes in body composition in colorectal cancer: a retrospective cohort study.

ABSTRACT:

Background

There is an emerging viewpoint that change in body weight is not sufficiently sensitive to promptly identify clinically meaningful change in body composition, such as skeletal muscle depletion.

Objectives

We aimed to determine whether body weight stability is associated with skeletal muscle depletion and whether skeletal muscle depletion is prognostic of death independently of change in body weight.

Methods

This retrospective cohort included 1921 patients with stage I-III colorectal cancer. Computed tomography (CT)-based skeletal muscle characteristics and body weight were measured at diagnosis and after a mean 15.0-mo follow-up. Body weight stability was defined as weight change less than ±5% during follow-up. Sarcopenia and myosteatosis were defined using

SUBMITTER: Brown JC 

PROVIDER: S-EPMC8168363 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature