An adiponectin receptor agonist promote osteogenesis via regulating bone-fat balance.

ABSTRACT:

Objectives

Adiponectin signalling has been considered to be a promising target to treat diabetes-related osteoporosis. However, contradictory results regarding bone formation were observed due to the various isoforms of adiponectin. Therefore, it would be necessary to investigate the effect of adiponectin receptor signals in regulating bone-fat balance.

Materials and methods

We primarily applied a newly found specific activator for adiponectin receptor, AdipoRon, to treat bone metabolism-related cells to investigate the role of Adiponectin receptor signals on bone-fat balance. We then established femur defect mouse model and treated them with AdipoRon to see whether adiponectin receptor activation could promote bone regeneration.

Results

We found that AdipoRon could s

SUBMITTER: Liu H 

PROVIDER: S-EPMC8168410 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature