Age-Related Changes in Cardiac Autonomic Modulation and Heart Rate Variability in Mice.

ABSTRACT:

Objective

The aim of this study was to assess age-related changes in cardiac autonomic modulation and heart rate variability (HRV) and their association with spontaneous and pharmacologically induced vulnerability to cardiac arrhythmias, to verify the translational relevance of mouse models for further in-depth evaluation of the link between autonomic changes and increased arrhythmic risk with advancing age.

Methods

Heart rate (HR) and time- and frequency-domain indexes of HRV were calculated from Electrocardiogram (ECG) recordings in two groups of conscious mice of different ages (4 and 19 months old) (i) during daily undisturbed conditions, (ii) following peripheral β-adrenergic (atenolol), muscarinic (methylscopolamine), and β-adrenergic + muscarinic blockades, and (iii)

SUBMITTER: Piantoni C 

PROVIDER: S-EPMC8168539 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature