Unknown

Dataset Information

0

Positive selective sweeps of epigenetic mutations regulating specialized metabolites in plants.


ABSTRACT: DNA methylation is an important factor regulating gene expression in organisms. However, whether DNA methylation plays a key role in adaptive evolution is unknown. Here, we show evidence of naturally selected DNA methylation in Arabidopsis thaliana In comparison with single nucleotide polymorphisms, three types of methylation-methylated CGs (mCGs), mCHGs, and mCHHs-contributed highly to variable gene expression levels among an A thaliana population. Such variably expressed genes largely affect a large variation of specialized metabolic quantities. Among the three types of methylations, only mCGs located in promoter regions of genes associated with specialized metabolites show a selective sweep signature in the A thaliana population. Thus, naturally selected mCGs appear to be key mutations that cause the expressional diversity associated with specialized metabolites during plant evolution.

SUBMITTER: Shirai K 

PROVIDER: S-EPMC8168577 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Positive selective sweeps of epigenetic mutations regulating specialized metabolites in plants.

Shirai Kazumasa K   Sato Mitsuhiko P MP   Nishi Ranko R   Seki Masahide M   Suzuki Yutaka Y   Hanada Kousuke K  

Genome research 20210518 6


DNA methylation is an important factor regulating gene expression in organisms. However, whether DNA methylation plays a key role in adaptive evolution is unknown. Here, we show evidence of naturally selected DNA methylation in <i>Arabidopsis thaliana</i> In comparison with single nucleotide polymorphisms, three types of methylation-methylated CGs (mCGs), mCHGs, and mCHHs-contributed highly to variable gene expression levels among an <i>A</i> <i>thaliana</i> population. Such variably expressed g  ...[more]

Similar Datasets

| S-EPMC3460923 | biostudies-literature
| S-EPMC8617496 | biostudies-literature
| S-EPMC4918448 | biostudies-literature
| S-EPMC7056974 | biostudies-literature
| S-EPMC3359763 | biostudies-literature
| S-EPMC10723294 | biostudies-literature
| PRJEB33224 | ENA
| S-EPMC4338236 | biostudies-literature
| S-EPMC10769429 | biostudies-literature
| S-EPMC11628914 | biostudies-literature