Linking the dynamics of chromatin occupancy and transcription with predictive models.

ABSTRACT: Though the sequence of the genome within each eukaryotic cell is essentially fixed, it exists within a complex and changing chromatin state. This state is determined, in part, by the dynamic binding of proteins to the DNA. These proteins-including histones, transcription factors (TFs), and polymerases-interact with one another, the genome, and other molecules to allow the chromatin to adopt one of exceedingly many possible configurations. Understanding how changing chromatin configurations associate with transcription remains a fundamental research problem. We sought to characterize at high spatiotemporal resolution the dynamic interplay between transcription and chromatin in response to cadmium stress. Whereas gene regulatory responses to environmental stress in yeast have been studied, h

SUBMITTER: Tran TQ 

PROVIDER: S-EPMC8168580 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature