Lipid signalling enforces functional specialization of T_reg cells in tumours.

ABSTRACT: Regulatory T cells (T_reg cells) are essential for immune tolerance¹, but also drive immunosuppression in the tumour microenvironment². Therapeutic targeting of T_reg cells in cancer will therefore require the identification of context-specific mechanisms that affect their function. Here we show that inhibiting lipid synthesis and metabolic signalling that are dependent on sterol-regulatory-element-binding proteins (SREBPs) in T_reg cells unleashes effective antitumour immune responses without autoimmune toxicity. We find that the activity of SREBPs is upregulated in intratumoral T_reg cells. Moreover, deletion of SREBP-cleavage-activating protein (SCAP)-a factor required for SREBP activity-in these cells inhibits tumour growth

SUBMITTER: Lim SA 

PROVIDER: S-EPMC8168716 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature