Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma.

ABSTRACT:

Background

High-grade meningiomas are aggressive tumors with high morbidity and mortality rates that frequently recur even after surgery and adjuvant radiotherapy. However, limited information is currently available on the biology of these tumors, and no alternative adjuvant treatment options exist. Although we previously demonstrated that high-grade meningioma cells were highly sensitive to gemcitabine in vitro and in vivo, the underlying molecular mechanisms remain unknown.

Methods

We examined the roles of hENT1 (human equilibrative nucleoside transporter 1) and dCK (deoxycytidine kinase) in the gemcitabine sensitivity and growth of meningioma cells in vitro. Tissue samples from meningiomas (26 WHO grade I and 21 WHO grade II/III meningiomas) were immunohistochemically ana

SUBMITTER: Yamamoto M 

PROVIDER: S-EPMC8168817 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature