The incidence of brain metastases among patients with metastatic breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Patients with metastatic breast cancer (MBC) are living longer, but the development of brain metastases often limits their survival. We conducted a systematic review and meta-analysis to determine the incidence of brain metastases in this patient population.

Methods

Articles published from January 2000 to January 2020 were compiled from four databases using search terms related to breast cancer, brain metastasis, and incidence. The overall and per patient-year incidence of brain metastases were extracted from studies including patients with human epidermal growth factor receptor-2 positive (HER2+), triple negative, and hormone receptor (HR)+/hormone receptor negative (HER2-) MBC; pooled overall estimates for incidence were calculated using random effects models.

SUBMITTER: Kuksis M 

PROVIDER: S-EPMC8168821 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature