Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response.

ABSTRACT: Aspergillus fumigatus is a human fungal pathogen that can cause devastating pulmonary infections, termed "aspergilloses," in individuals suffering immune imbalances or underlying lung conditions. As rapid adaptation to stress is crucial for the outcome of the host-pathogen interplay, here we investigated the role of the versatile posttranslational modification (PTM) persulfidation for both fungal virulence and antifungal host defense. We show that an A. fumigatus mutant with low persulfidation levels is more susceptible to host-mediated killing and displays reduced virulence in murine models of infection. Additionally, we found that a single nucleotide polymorphism (SNP) in the human gene encoding cystathionine γ-lyase (CTH) causes a reduction in cellular persulfidation and correlates with

SUBMITTER: Sueiro-Olivares M 

PROVIDER: S-EPMC8168846 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature