Autonomic biomarkers of shock in idiopathic systemic capillary leak syndrome.

ABSTRACT:

Objective

The term Idiopathic Systemic Capillary Leak Syndrome (ISCLS) refers to an uncommon condition of severe distributive shock, resulting from an abrupt shift of fluids and proteins from the intravascular to the interstitial compartment. We hypothesise that the autonomic nervous system (ANS) fails in regulating the response to hypovolemia in acute ISCLS and that ANS variables characterise the progression to the recovery.

Design

Prospective cohort study of patients admitted to ICU for severe ISCLS flares.

Setting

Single, referral center in Italy for ISCLS.

Patients

Analysis of cardiovascular signals recorded during seven severe ISCLS attacks and one prodromal period in five patients.

Interventions

ANS was studied non-invasively by means of heart rate

SUBMITTER: Wu MA 

PROVIDER: S-EPMC8168872 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature