Hyperexpression of CDRs and HWP1 genes negatively impacts on Candida albicans virulence.

ABSTRACT: C. albicans is a commensal organism present in the human microbiome of more than 60% of the healthy population. Transition from commensalism to invasive candidiasis may occur after a local or a general failure of host's immune system. This transition to a more virulent phenotype may reside either on the capacity to form hyphae or on an acquired resistance to antifungal drugs. Indeed, overexpression of genes coding drug efflux pumps or adhesins, cell wall proteins facilitating the contact between the fungus and the host, usually marks the virulence profile of invasive Candida spp. In this paper, we compare virulence of two clinical isolates of C. albicans with that of laboratory-induced resistant strains by challenging G. mellonella larvae with these pathogens along with monitoring transcri

SUBMITTER: Maras B 

PROVIDER: S-EPMC8168907 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature