Gut microbiome pattern reflects healthy ageing and predicts survival in humans.

ABSTRACT: The gut microbiome has important effects on human health, yet its importance in human ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late adulthood, gut microbiomes become increasingly unique to individuals with age. We leverage three independent cohorts comprising over 9,000 individuals and find that compositional uniqueness is strongly associated with microbially produced amino acid derivatives circulating in the bloodstream. In older age (over ~80 years), healthy individuals show continued microbial drift towards a unique compositional state, whereas this drift is absent in less healthy individuals. The identified microbiome pattern of healthy ageing is characterized by a depletion of core genera found across most humans, primarily Bacteroides. Ret

SUBMITTER: Wilmanski T 

PROVIDER: S-EPMC8169080 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature