Gut microbiome pattern reflects healthy ageing and predicts survival in humans.
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ABSTRACT:
SUBMITTER: Wilmanski T
PROVIDER: S-EPMC8169080 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Gut microbiome pattern reflects healthy ageing and predicts survival in humans.
Wilmanski Tomasz T Diener Christian C Rappaport Noa N Patwardhan Sushmita S Wiedrick Jack J Lapidus Jodi J Earls John C JC Zimmer Anat A Glusman Gustavo G Robinson Max M Yurkovich James T JT Kado Deborah M DM Cauley Jane A JA Zmuda Joseph J Lane Nancy E NE Magis Andrew T AT Lovejoy Jennifer C JC Hood Leroy L Gibbons Sean M SM Orwoll Eric S ES Price Nathan D ND
Nature metabolism 20210218 2
The gut microbiome has important effects on human health, yet its importance in human ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late adulthood, gut microbiomes become increasingly unique to individuals with age. We leverage three independent cohorts comprising over 9,000 individuals and find that compositional uniqueness is strongly associated with microbially produced amino acid derivatives circulating in the bloodstream. In older age (over ~80 years) ...[more]
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