Plasma Endogenous Sulfur Dioxide: A Novel Biomarker to Predict Acute Kidney Injury in Critically Ill Patients.

ABSTRACT:

Purpose

Sulfur dioxide (SO₂) is a novel gaseous signaling molecule that plays an important role in inflammation, which contributes the pathogenesis of acute kidney injury (AKI). The aim of this study was to explore the predictive value of plasma SO₂ for AKI in high-risk patients.

Patients and methods

A prospective cohort of 167 patients who underwent major noncardiac surgery was enrolled in the study. Plasma SO₂, urine neutrophil gelatinase-associated lipocalin (NGAL), tissue inhibitor of metalloproteinase-2 (TIMP-2), and insulin-like growth factor-binding protein 7 (IGFBP7) levels were detected immediately after the operation. The primary endpoint was new-onset AKI within 72 h after admission. The ability of biomarkers including SO₂

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8169086 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature