Sustained low-dose interleukin-2 therapy alleviates pathogenic humoral immunity via elevating the Tfr/Tfh ratio in lupus.

ABSTRACT:

Objectives

Low-dose interleukin-2 (IL-2) has shown promising clinical benefits in the treatment of systemic lupus erythematosus (SLE), but how this therapy alleviates pathogenic humoral immunity remains not well understood. The dilemma is that IL-2 can suppress both follicular helper and regulatory T (Tfh and Tfr) cells, which counteract each other in regulating autoantibody production.

Methods

Female NZB/W F1 mice received recombinant human IL-2 (3 × 10⁴ IU/dose) in three treatment regimens: (1) short, daily for 7 days; (2) medium, daily for 14 days, and (3) long, every second day for 28 days. Tfh (Foxp3^-CXCR5⁺Bcl6⁺), Tfr (Foxp3⁺CXCR5⁺Bcl6⁺), germinal centre (GC, B220⁺GL-7⁺Fas

SUBMITTER: Liang K 

PROVIDER: S-EPMC8169300 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature