Effects of passage through the digestive tract on incretin secretion: Before and after birth.

ABSTRACT:

Aims/introduction

It was reported that fetuses secrete endogenous incretin; however, the stimulants of fetal incretin secretion are not fully understood. To investigate the association between the passage of amniotic fluid through the intestinal tract and fetal secretion of incretin, we analyzed umbilical cord incretin levels of infants with duodenum atresia.

Materials and methods

Infants born from July 2017 to July 2019 (infants with duodenum atresia and normal term or preterm infants) were enrolled. We measured and compared the concentrations of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide/glucose-dependent insulinotropic polypeptide (GIP) in the umbilical vein and preprandial blood samples after birth.

Results

A total of 98 infants (47 term, 46 pr

SUBMITTER: Tomotaki S 

PROVIDER: S-EPMC8169361 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature