Molecular epidemiology of SARS-CoV-2 isolated from COVID-19 family clusters.

ABSTRACT:

Background

Transmission within families and multiple spike protein mutations have been associated with the rapid transmission of SARS-CoV-2. We aimed to: (1) describe full genome characterization of SARS-CoV-2 and correlate the sequences with epidemiological data within family clusters, and (2) conduct phylogenetic analysis of all samples from Yogyakarta and Central Java, Indonesia and other countries.

Methods

The study involved 17 patients with COVID-19, including two family clusters. We determined the full-genome sequences of SARS-CoV-2 using the Illumina MiSeq next-generation sequencer. Phylogenetic analysis was performed using a dataset of 142 full-genomes of SARS-CoV-2 from different regions.

Results

Ninety-four SNPs were detected throughout the open reading fram

SUBMITTER: Gunadi 

PROVIDER: S-EPMC8169432 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature