Cord serum metabolome and birth weight in patients with gestational diabetes treated with metformin, insulin, or diet alone.

ABSTRACT:

Introduction

Recent research has demonstrated the benefits of metformin treatment in gestational diabetes (GDM) on short-term pregnancy outcomes (including excessive fetal growth and pre-eclampsia), but its effects on fetal metabolism remain mostly unknown. Our aim was to study the effects of metformin treatment compared with insulin or diet on the cord serum metabolome and also to assess how these metabolites are related to birth weight (BW) in pregnancies complicated by GDM.

Research design and methods

Cord serum samples were available from 113, 97, and 98 patients with GDM treated with diet, insulin, and metformin, respectively. A targeted metabolome was measured using nuclear magnetic resonance spectroscopy. The patients in the metformin and insulin groups had participat

SUBMITTER: Huhtala MS 

PROVIDER: S-EPMC8169462 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature