Mouse models for mesothelioma drug discovery and development.

ABSTRACT:

Introduction

Mesothelioma is an aggressive mesothelial lining tumor. Available drug therapies include chemotherapeutic agents, targeted molecular therapies, and immune system modulators. Mouse models were instrumental in the discovery and evaluation of such therapies, but there is need for improved understanding of the role of inflammation, tumor heterogeneity, mechanisms of carcinogenesis, and the tumor microenvironment. Novel mouse models may provide new insights and drive drug therapy discovery that improves efficacy.

Areas covered

This review concerns available mouse models for mesothelioma drug discovery and development including the advantages and disadvantages of each. Gaps in current knowledge of mesothelioma are highlighted, and future directions for mouse model res

SUBMITTER: Seastedt KP 

PROVIDER: S-EPMC8169513 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature