Combination Immunotherapy With LIGHT and Interleukin-2 Increases CD8 Central Memory T-Cells In Vivo.

ABSTRACT:

Background

The generation of long-term durable tumor immunity and prolonged disease-free survival depends on the ability to generate and support CD8+ central memory T-cells. Microsatellite-stable colon cancer is resistant to currently available immunotherapies; thus, development of novel mechanisms to increase both lymphocyte infiltration and central memory formation are needed to improve outcomes in these patients. We have previously demonstrated that both interleukin-2 (IL-2) and LIGHT (TNFSF14) independently enhance antitumor immune responses and hypothesize that combination immunotherapy may increase the CD8+ central memory T-cell response.

Methods

Murine colorectal cancer tumors were established in syngeneic mice. Tumors were treated with control, soluble, or liposomal

SUBMITTER: Fernandez MF 

PROVIDER: S-EPMC8169541 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature