Novel ligands and modulators of triggering receptor expressed on myeloid cells receptor family: 2015-2020 updates.

ABSTRACT: Introduction: Triggering receptors expressed on myeloid cells (TREMs) are inflammatory amplifiers with defined pathophysiological role in various infectious diseases, acute and chronic aseptic inflammations, and a variety of cancers, depicting TREMs as prominent therapeutic targets.Areas covered: Herein, updates from 2015 to 2020 are discussed to divulge the TREM ligands, as well as their peptide blockers, claimed to modulate their expression. The article also presents different strategies employed during the last five years to block interactions between TREMs and their ligands to treat various disease conditions by modulating their expression and activity.Expert opinion: There has been significant progress in the discovery of novel ligands and modulators of TREMs in t

SUBMITTER: Singh H 

PROVIDER: S-EPMC8169545 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature