The glucocorticoid receptor specific modulator CORT108297 reduces brain pathology following status epilepticus.

ABSTRACT:

Objective

Glucocorticoid levels rise rapidly following status epilepticus and remain elevated for weeks after the injury. To determine whether glucocorticoid receptor activation contributes to the pathological sequelae of status epilepticus, mice were treated with a novel glucocorticoid receptor modulator, C108297.

Methods

Mice were treated with either C108297 or vehicle for 10 days beginning one day after pilocarpine-induced status epilepticus. Baseline and stress-induced glucocorticoid secretion were assessed to determine whether hypothalamic-pituitary-adrenal axis hyperreactivity could be controlled. Status epilepticus-induced pathology was assessed by quantifying ectopic hippocampal granule cell density, microglial density, astrocyte density and mossy cell loss. Neuronal

SUBMITTER: Wulsin AC 

PROVIDER: S-EPMC8169587 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature