Transcriptomic expression of AMPA receptor subunits and their auxiliary proteins in the human brain.

ABSTRACT: Receptors to glutamate of the AMPA type (AMPARs) serve as the major gates of excitation in the human brain, where they participate in fundamental processes underlying perception, cognition and movement. Due to their central role in brain function, dysregulation of these receptors has been implicated in neuropathological states associated with a large variety of diseases that manifest with abnormal behaviors. The participation of functional abnormalities of AMPARs in brain disorders is strongly supported by genomic, transcriptomic and proteomic studies. Most of these studies have focused on the expression and function of the subunits that make up the channel and define AMPARs (GRIA1-GRIA4), as well of some accessory proteins. However, it is increasingly evident that native AMPARs are compos

SUBMITTER: Shen K 

PROVIDER: S-EPMC8169612 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature