Prediction of transient ischemic attack and minor stroke in people with type 2 diabetes mellitus.

ABSTRACT:

Aims

People with type 2 diabetes (T2DM) have an increased risk of transient ischemic attack and minor stroke (TIA) which are frequently followed by an ischemic stroke. We aimed to develop a predictive model for incident TIA in people with T2DM.

Methods

We pooled data from two longitudinal cohort studies, Atherosclerosis Risk in Communities (ARIC) and the Cardiovascular Health Study (CHS), using a two-stage approach. First, we used a random effects model to interpolate risk factors of individuals between follow-up exams. Second, we used forward selection to develop a proportional hazards model for time to incident TIA. We internally validated our model using 10-fold cross-validation.

Results

Among 3575 participants with T2DM, mean (SD) age was 60 (10) years and body ma

SUBMITTER: Isaman DJM 

PROVIDER: S-EPMC8169622 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature